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KMID : 0438219730100030717
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Korea University Medical Journal
1973 Volume.10 No. 3 p.717 ~ p.729
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Effects of Vitamin E on the Kidney in the Mouse by Histological Method
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Abstract
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To assess the effects of vitamin E on the renal tissue of the albino mouse depending upon the enforced conditions was the objective of the studies. Vitamin E was administered on a daily dose of 5mg; 10 days for the first subgroup and 20 days for the second subgroup, while another similar groups of mice were maintained on a deficiency state. A comparison of the histological changes was made amongst the administered, deficient and control group.
The results of the studies are summarized as follows:
1. It is concluded that vitamin E administration on the above basis has definite influence on the morphological structure of the renal tissue. A 10-day injection of vitamin E was sufficient for adequate state, while a 20-day injection resulted in excessively pronounced changes.
2. Contrasted with the normal mice kidney cortex, an increase in the number of glomeruli was noted in the vitamin E administered group. Conversely, a decrease in the number of glomeruli occurred in the deficient group, specially to a greater degree in the long term deficient group.
3. Without exception, hypertrophy of the epithelial lining cells of the Bowman´s capsule with a prominence of columnar or cuboidal cells was observed among the adult mature male animal for a long term experimental group.
4. In the deficiency group, widening of the lumen and flattening of the epithelial cells of the straight collecting tubule and papillary duct were observed. On the other hand, tall columnar cells dominated the epithelium of the vitamin E administered group.
5. The vitamin E deficiency groups showed the least resistance to postmortem histolysis while the greatest resistance was afforded by the 10-day injected group.
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